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| DATE # |
Researcher/Research Findings/Publication | Adverse Reaction Identified | Funding Source |
| 1970 #1 |
Olney, JW Brain Damage in Infant Mice Following Oral Intake og Glutamate, Asparate, or Cysteine. Nature 1970;227-609-610. |
Adverse Reaction Identified |
Washington University |
| 1975 #2 |
Olney, JW Aspartame as a Sweetner |
Adverse Reaction Identified |
Washington University School of Medicine |
| 1977 #3 |
Mishiro Y, Kaneko II Effect of Dipeptide, Aspartame on Lactic Acid Production in Human Whole Saliva Journal Dental Res 1977;56(11);1427 |
Adverse Reaction Identified |
Nippon Dental University, Japan |
| 1979 #4 |
Brunner, RL, Vorhees CV, Kinney L, Butcher, RE et.al. Aspartame: Assesment of Developmental Psychotoxicity of a New Artificial Sweetner Neurobehavorial Toxicology 1979;1:79-86. |
Adverse Reaction Identified |
FDA |
| 1979 #4 |
Stegink LD, Filer LJ, Baker GL Effects of Aspartame loading upon plasma and erthyrocyte amino acid levels in phenylketonuria heterozygotes and normal adult aubjects. *See further observation study done in 1990. Journal Nutrition 109:708-717 |
Adverse Reaction Identified |
None Specified |
| 1979 #5 |
Olney JW Brain Damage in Mice from Voluntary Ingestion of Glutamate and Asparate Neurobehavorial Toxicology and Teraology 1980;2:125-129. |
Adverse Reaction Identified |
Washington University |
| 1982 #6 |
Uribe Potential Toxiocity of a New Sugar Substitute in Patients with Liver Disease New England Journal of Medicine 1982; 173-174 |
Adverse Reaction Identified |
M.I.T. |
| 1983 #7 |
Wurtman, RJ Effects of Aspartame and Glucose on Rat Brain Amino Acids and Serotonin New England Journal of Medicine 1983; 309(7) 429-430 |
Adverse Reaction Identified |
M.I.T. |
| 1983 #8 |
Wurtman, RJ Neurological Changes Following High Dose Aspartame with Dietary Carbohydrates New England Journal of Medicine 1983;309(7):429-430 |
Adverse Reaction Identified |
M.I.T. |
| 1984 #9 |
Olney, JW Excitotoxic Food Additives - Revelance of Animal Studies to Human Safety Neurobehavorial Toxicology and Teratology. 1984;6:455-462 |
Adverse Reaction Identified |
Research Science Award M.I.T. |
| 1984 #10 |
Monte Aspartame: Methanol and the Public Health Journal Applied Nutrition 36(1):42-54. |
Adverse Reaction Identified |
Arizone State University M.I.T. |
| 1984 #11 |
Yokogoshi H, Roberts CH, Canballero B, Wurtman RJ, Effects of Aspartame and Glucose Adminstration on Brain and Plasma Levels of LArge Neural Amino ACids and Brain 5-Hydroxyindoles American Journal Clinical Nutrition 1984:40:1-7. |
Adverse Reaction Identified |
M.I.T |
| 1984 #12 |
Mahalik MP, Gautieri RF Reflex Responsiveness of CF-1 Mouse Neonates Following Maternal Aspartame Exposure Research Communications in Psychology, Psychiatry & Behavior, 1984:9(4):385-403. |
Adverse Reaction Identified |
None Specified |
| 1985 #12 |
Novick Aspartame Induced Granilomatous Panniculitis Annual Internal Medicine, 102(2):206-207. |
Adverse Reaction Identified |
Mt. Sinai Medical Center |
| 1985 #13 |
Grobelny D, Galardy RE A Metabolite of Aspartame Inhibits Angiostein Converting Enzynme Biochemical & BioPhysical Research Communications, 1985:128(2):960-964 |
Adverse Reaction Identified |
University of Kentucky |
| 1985 #14 |
Wurtman RJ Aspartame: Possible Effects on Seizure Suspectibility Lancet, 1985;2(8463):1060 |
Adverse Reaction Identified |
M.I.T. |
| 1985 #15 |
Ferguson A Jr. Interaction of Aspartame and Carbohydrates in an Eating Disordered Patient American Journal Psych 1985, Feb. 142(2):271 |
Adverse Reaction Identified |
None |
| 1986 #16 |
Kulczycki A Jr. Aspartame Induced Urticaria Annual Internal Medicine 1986:104(2):207-208 |
Adverse Reaction Identified |
National Institute Of Health |
| 1986 #17 |
Pardridge WM The Safety of Aspartame (Letter) JAMA, 1986:256(19):2678 |
Adverse Reaction Identified |
UCLA School Of Medicine |
| 1986 #18 |
Koehler SM, A New Dietary Caution for Migraine Sufferers Aspartame - Applied Nutition 1986;1:1-7 |
Adverse Reaction Identified |
Center for Brain Sciences and Metabolism, Charitable Trust & University of Florida |
| 1986 #19 |
Kiritsky and Maher TJ Accute Effects of Aspartame on Systolic Blood Pressure in Spontaneously Rats. - Journal of Neural Transmission 1986;66(2): 121-128 |
Adverse Reaction Identified |
National Institute of Neurological, Communicative Diseases and Stroke |
| 1986 #20 |
Yukogoshi II and Wurtman RJ Acute Effects of Oral or Parenteral Aspartame on Catecholamine Metabolism in Various Regions of Rat Brain - Journal of Nutrition 1986; 116:356-364 |
Adverse Reaction Identified |
M.I.T. |
| 1986 #21 |
Walton, Seizure and Mania After High Intake of Aspartame. - Psychosomatics 27:218-220 |
Adverse Reaction Identified |
Chautauqua County Dept. of Mental Health M.I.T. |
| 1986 #22 |
Drake ME, Panic Attacks and Excessive Aspartame Ingestion (Letter). - Lancet 1986;2(8507):631 |
Adverse Reaction Identified |
None |
| 1986 #23 |
Johns DR, Migraine Provoked by Aspartame. - New England Journal of Medicine 1986:315(7):456 |
Adverse Reaction Identified |
None |
| 1986 #24 |
Blundell JE, Hill AJ, Paradoxial Effects of Intense Sweetner Aspartame on Appetite - Lancet 1986;(8489):1092-3 |
Adverse Reaction Identified |
None |
| 1987 #25 |
Caballero B, Mahon BE, Rohr Fl, Levy IlL, Wurtman RJ, et. al., Plasma Amino Acid Levels After Single Dose Aspartame Consumption in Phenylketonuria Mild II Hyperphenylalaninemia and Heterozygous State for Phenylkeonuria. - Journal of Pediatrics 1986; 109(4):668-67 I. |
Adverse Reaction Identified |
National Institute of Neurological Communicate Diseases and Stroke |
| 1987 #26 |
Bradstock MK, Serdula MK, Marks IS, et al. Evaluation of Reactions to Food Additives: The Aspartame Experience American Journal Clinical Nutrition 1986 Mar;43(3):464-9 | Adverse Reaction Identified |
Federal Government |
| 1987 #27 |
Coulombe PA Jr., Sharma R P Neurobiochemical Alterations Induced by the Artificial Sweetner Aspartame. - Toxicol Appl Pharmacol 1986;83(1):79-85 |
Adverse Reaction Identified |
Utah State University |
| 1987 #28 |
Wurtman RI, Aspartame Effects on Brain Serotonin. - American Journal Clinical Nutrition 1987 April; 45(4):799-803 |
Adverse Reaction Identified |
M.I.T. |
| 1987 #29 |
Maher TJ and Wurtman RJ, Neurologic Effects of Aspartame A Widely Used Food Additive - Environmental Health Perspectives 1987;75:53-57 |
Adverse Reaction Identified |
M.I.T. and Federal Govt. |
| 1987 #30 |
Drogari E., Smith I, Beasley M, Lloyd JK Timing of Strict Diet Relation to Fetal Damage in Maternal Phenylketonoruia An International Collaborative Study by MRC/DISS Phenylketonurioa Register - Lancet, 1987;2(8565):927-30 |
Adverse Reaction Identified |
Institute of Child Health |
| 1987 #31 |
Elsas, et al. Changes in Physiological Concentrations of Blood Phenylalanine Produce Changes in Human Brain Function. - Dietary Phenylalanine and Brain Function, Birkhauser, Boston 1988; 187-195 |
Adverse Reaction Identified |
Emory University |
| 1988 #32 |
Roberts; Neurological, Psychiatric and Behavioral Reactions to Aspartame in 505 Aspartame Reactors. In: Wurtman and Ritter-Walker (eds.). dietary Phenylalamine and Brain Function. Boston: Birkhauser, 1988, pp 373-376 |
Adverse Reaction Identified |
Palm Beach Institute for Medical Research |
| 1988 #33 |
Pinto and Maher Aspartame, Phenylalanine and Seizures in Experimental Animals. - In: Wurtman and Ritter-Walker (eds) Dietary Phenylalamine and Brain Function Boston: Birkhauser,1988 pp. 96-103 |
Adverse Reaction Identified |
National Institute of Neurological and Communicative Diseases and Stroke |
| 1988 #34 |
Roberts Reactions Attributed to Aspartame Containing Products: 551 Cases Journal of Applied Nutrition 1988; 40: 85-94 |
Adverse Reaction Identified |
Palm Beach Institute for Medical Research |
| 1988 #35 |
Neurologic Pshychiatric and Behavorial Reactions to Aspartame in
505 Aspartame Reactors. In: Wuirtman and Ritter-Walker (eds.) Distery Phenylalanine and Brain Function. Boston:Buckharuser, 1988, pp.373-376 |
Adverse Reaction Identified |
NONE |
| 1988 #36 |
Wurtman and Maher Calculation of Aspartame Dose for Rodents that Produces Neurochemical Effects Comparable to Those Occuring in People. In: Wurtman and Ritter-Walker (eds) Dietary Phenylalanine and Brain Function Boston: Birkhauser, 1988, pp 144-148 |
Adverse Reaction Identified |
M.I.T. |
| 1988 #37 |
Pinto JM, Mahea TJ Adminstration of Aspartame Potentiates Pentylenetetrazole and Fluorothy Induced Seizures in Mice Neuropharmacology 1988;27(1):51-55 |
Adverse Reaction Identified |
National Institute of Neurological & Communicative Diseases and Strokes |
| 1988 #38 |
Walton The Possible Role of Aspartame in Seizure Induction Proceedings of the First International Confererence on Phenylalanine and the Brain Function In: Wurtman, R.L., Walker E. (eds) Center for Brain Sciences and Metabolism Charitable Trust, Cambridge 1987 |
Adverse Reaction Identified |
Chautaugua County Dept of Mental Health |
| 1988 #39 |
Olney, Excitotoxic Food Additives - Funcitonal Teratological Aspects. In Progress in Brain Research, Vol 73 - Biochemical Basis of Functional Neuroteratolgy: Permenent Effects of Checmical on Developing Brain, edited by Boer, GI, etc. al., Elsevier, New York 1988. |
Adverse Reaction Identified |
Washington State University |
| 1988 #40 |
Steinmetzner and Kunkel, Aspartame and Headache *(Letter). New England Journal of Mediciine, 1988;318(18):1201 |
Adverse Reaction Identified |
Cleveland Clinic |
| 1988 #41 |
Spiers, et. al. Aspartame and Human Behavior: Cognitive and Behavorial Observations, In: Wurtman and Ritter-Walker, (eds.) Dietary Phenylalanine and Brain Function, Boston: Birkhauser, 1988 pp. 169-178 |
Adverse Reaction Identified |
Center for Brain Sciences and Metabolism Charitable Trust |
| 1988 #42 |
Sardeal, et. al. Effect of Aspartame in Diabetic Rats. In: Wurtman and Ritter-Walker (eds.) Dietary Phenylalanine and Brain Function Boston: Birkhauser, 1988, pp.265-268 |
Adverse Reaction Identified |
Wayne State University |
| 1988 #43 |
1988 Matalou, e.t. al. Aspartame Comsumption in Normal Individuals and Carriers for Phenylketonuria In: Wurtman and Ritter-Walkers (eds.) Dietary Phenylalanine and Brain Function Boston: Birkhauser, 1988, pp.41-52 |
Adverse Reaction Identified |
N.I.H. and The University of Illinos |
| 1988 #44 |
Guiso G., Caccia S., Vezzani Al. Effect of Aspartame on Seisures on Various Models of Experimental Epilepsy Toxicology and Applied Pharmacology. 1988;96:485-493 |
Adverse Reaction Identified |
Istituto di Ricerche Farmcologiche (Italy) Mario Negri, Via Eritea |
| 1988 #45 |
Johns, Aspartame and Headache. In: Wurtman and Ritter-Walkers (eds.) Dietary Phenylalamine and Brain Function. Boston: Birkhasuer, 1988, pp. 303-312 |
Adverse Reaction Identified |
John Hopkins University |
| 1988 #46 |
Fernstrom Effects of Aspartame Ingestion on Large Neutral Amino Acids and Monoamine and Neurotransmitters in the Central Nervous System. In: Wurtman and Ritter-Walker (eds.) Dietary Phenylalamine and Brain Function. Boston: Birkhauser, 1988, pp.87-96 |
Adverse Reaction Identified |
N.I.M.H. |
| 1988 #47 |
Maher and Kiritsy Aspartame Decreases the Entry of Alpha-Methyldopa into the Brain of Rats. In: Wurtman and Ritter-Walker, (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhasuer, 1988, pp.1222-126 |
Adverse Reaction Identified |
Massachuetts College of Pharmacy |
| 1988 #48 |
Elsas, Aspartame and Migraine New Engalnd Journal of Medicine, 1988;318(18):1201. |
Adverse Reaction Identified |
Emory University |
| 1988 #49 |
Kim, et. al. The effect of Aspartame on 50% Convulsion Doses of Lidocaine. In: Wurtman and Ritter-Walker, (eds.) Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp.127-130 Indiana University and Ball State University |
Adverse Reaction Identified |
University of Leeds |
| 1988 #50 |
Blundell Effects of Aspartame on Appetite and Food Intake. In Dietary Phenylalanine and Brain Function, Wurtman and Ritter-Walker, Ediots, 1988, Birkhauser, Bonston pp. 275-295 |
Adverse Reaction Identified |
Albert Einstein College of Medicine |
| 1988 #51 |
Lipton, R.B., Newman, L.C., Cohen, J.S. Aspartame and Headache. New England Journal of Medicine, 1988, May 5:1200. |
Adverse Reaction Identified |
National Headache Foundation |
| 1988 #52 |
Lipton, et. al. Aspartame as a Dietary Factor in Headache. Neurology. 1988: 38: 356 |
Adverse Reaction Identified |
National Headache Foundation |
| 1988 #53 |
Liton, et. al., Aspartame as a Dietary Trigger of Headache. Headache, 1989;29(2);90-2 |
Adverse Reaction Identified |
National Headache Foundation |
| 1988 #54 |
Koehler SM, Glaros A. The Effect of Aspartame on Migraine Headaches Headache, 1988; 28:10-13 |
Adverse Reaction Identified |
Center for Brains Sciences and Metabolism Chartible Trust and The University of Florida |
| 1989 #55 |
Ptenza, DD, and el-Mallakh RS. Aspartame: Clinical Update. Connective Medicine, 1989;53(7): 395-400 |
Adverse Reaction Identified |
No Funding Source |
| 1989 #56 |
Holder MD and Yirmuya, R. Behavioral Assesment of the Toxicity of Aspartame Pharmaclology and Bio Chemistry Pharmacology Biochemistry and Behavior 1989;32;1726 |
Adverse Reaction Identified |
National Institutes of Health |
| 1989 #57 |
Dow-Edwards, DL. Scribani, LA. Rikey, EP, at. al. Imparied Performance on Odor-Aversion Testing Following Prenatal Aspartame Exposure in the Guinea Pig. Neurotoxicology and Tetratology. 1989, Jul.Aug-:11(4):413-416. |
Adverse Reaction Identified |
Laboratory of Cerebral Metabolism State University of New York |
| 1989 #58 |
Dow-Edwards DL, Scribani LA, Riley EP, Imparied Performance on Odor-Aversion Testing Following Prenatal Aspartame Exposure in the Guinea Pig Neurotoxicol Teratol 1989, 11(4):413-416. |
Adverse Reaction Identified |
State University of New York |
| 1989 #59 |
Bresnick Excitoxins: A Possible New Mechanism for hte Pathogenesis of Ischemic Retinal Damage Arch Opmalmology, 1989 Mar;107(3):339-341. |
Adverse Reaction Identified |
National Institutes of Health |
| 1989 #60 |
Tudoff MG, and Alleva AM, Oral Stimulation with Aspartame Increases Hunger Psyhsiology Behavior 1990;47(3):555-9 |
Adverse Reaction Identified |
None Specified |
| 1989 #61 |
Pan-Hou J, et. al. Effect of Aspartame on N-Methyl-D Asparate Sensitive L-(311) Glutamate Binding Sites in Rat Brain Synpatic Membranes. Brain Res. 1990;520(1-2):351-353. |
Adverse Reaction Identified |
Setsunan University-Japan |
| 1989 #62 |
Strathman Recurrent Vulvovaginitis Resulting from Heavy Dietary Use of Aspartame Journal Reproductive Medicine, 1991 Aug;36(8):572 |
Adverse Reaction Identified |
NO Source |
| 1989 #63 |
Roberts Does Aspartame Cause Human Bran Cancer Journal of Advancement in Medicine 4(4):231-241. |
Adverse Reaction Identified |
NONE |
| 1990 #4 |
Stegink LD, Filer LJ, Baker GL Repeated ingstion of aspartame-sweetened beverahges: Further observations individuals heterozygous for phenylketonuria. * See study first done in 1979. Metabolism 39(10):1076-1081. |
Adverse Reaction Identified |
None Specified |
| 1990 #64 |
Watts RS, Aspartame, Headaches and Beta Blockers Headache 1991:31(3):181-182 |
Adverse Reaction Identified |
NONE |
| 1991 #65 |
McCauliffe DP, Poitras K, et. al. Aspartame-Induced Lobular Panniculitis Journal American Acadmy Dermatology, 1991;24(2 pt1):298-300 |
Adverse Reaction Identified |
U.S. Air Force |
| 1991 #66 |
Moller SF, Effect of Aspartame and Protein Administered to Phyenlalanine-Equivalent Doses on Plasma Neutral Amino ACids, Asparatate, Insulin and Glucose in Man. Pharmacology Toxicilogy 1991;68(5):408-412 |
Adverse Reaction Identified |
St. Hans Hospital, Denmark |
| 1991 #67 |
Diomed L., Romano M.,Guiso G., etl. al. Interpspecies and Interstrain Studies on the Increased Susceptibility to Metrazol-Induced Convulsions in Animals given Aspartame. Food and Chemical Toxicology 1991;29(2):101-106. |
Adverse Reaction Identified |
Istituto di Richerche Farmachologiche, Mario Begri, Milan Italy |
| 1991 #68 |
Guiso, et. al. Effect of Tyrosine on the Potentiation of Aspartame and Pheylalamine of Metrazol-Induced Convulsions in Rats. Food Chemical Toxicology. 1991 Dec;29(12):855-857 |
Adverse Reaction Identified |
Istituto di Richerche Farmachologiche, Mario Begri, Milan Italy |
| 1992 #69 |
Camfield PR, Camfield CS, Dooley JM, et. al. Aspartame Exerbates EEG Spike Wave Discharge in Children with Generalized Absence Epilepsy A Double Blind Controlled Study. Neurology 1992;42:1000-1003. |
Adverse Reaction Identified |
Ontario Minstry of Health, Canada |
| 1992 #70 |
Gulya AJ, Sessions RB, Troost TR, et. al. Aspartame and Dizziness, Preliminary Results of a Prospective, Nonblinded, Prevalence and Attempted Cross-Over Study. American Journal of Otology 192 Sep:13(5):438-442. |
Adverse Reaction Identified |
Georgestown University |
| 1993 #71 |
Shepard SE, Wakabayshi K, Nagao M. et. al. Mutagenic Activity of Peptides and the Artificial Sweetner Aspartame After Nitrosation. Food & Chemical Toxicology 1993;31(5);323-329. |
Adverse Reaction Identified |
National Cancer Center Research - Institute - Japan |
| 1993 #72 |
Walton RG, Hudak R, Grreenwaite RJ, Adverse Reaction to Aspartame - Double Blinded Challenge to Patients from a Vulnerable Population. Biological Psychiartry 1993;34(1-2);13-17 |
Adverse Reaction Identified |
Western Reserve Care System |
| 1993 #73 |
Eshel Y, and Sarova-Pincus I Aspartame and Seizures Neurology, 1993;43(10):2154-2155 |
Adverse Reaction Identified |
NONE |
| 1993 #74 |
Kasamaki A, Uresaw S et. al. The Effect of Food Chemicals on Cell Aging of Human Diploid Cells in Vitro Culture Journal Toxicology Sci. 1993l18(3): 143-153 |
Adverse Reaction Identified |
Sapparo Medical College - Japan |
| 1993 #75 |
Meldrum Amino Acids as Dietary Excitotoxins: A Contribution to Understanding Neurodegenerative Disorders Brain Res Rev 1993: Sep-Dec;18(3):293-314 |
Adverse Reaction Identified |
Institute of Psychiatry - London |
| 1994 #76 |
Van Den Eeden SK, Koepsell TD, Landstreth WT Jr. et. al. Aspartame Ingestion and Headaches: A Randomized Crossover Trial. Neurology 1994;44(10):1787-1793 |
Adverse Reaction Identified |
University of Washington |
| 1994 #79 |
Olney Excitotoxins in Foods Neurotoxicology 1996: 15(3):535-544 |
Adverse Reaction Identified |
Washington University |
| 1994 #80 |
Gerrad JW, Richardson JS, Donat J, et. al. Neuropharmacological Evaltuation of Movement Disorders that are Adverse Reactions to Specific Foods Including Aspartame. International Journal of Neurosciences 1994 May;76(1-2):61-69. |
Adverse Reaction Identified |
University of Saskatchewan, Canada |
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