HOME Previous Columns Email Contacts Advertising

These (11) studies deal specifically with insulin resistance/effectiveness caused by trans fatty acids from hydrogenated oils. The full studies can be pulled up on Pub/Med. These are just a sample of over 120 such studies that prove the harmful effects of trans fatty acids, trans-isomers on the body that cause diabetes, coronary heart disease, breast cancer, other cancers, auto-immune disorders, attention deficit disorders and more! You can only pull the full studies if you have a logon ID from a Medical University Library on Pub/Med. You can get this by going in to a University Medical Library and acquiring one.

1:) Title: Is insulin resistance influenced by dietary linoleic acid and trans fatty acids?
Free Radic Biology Medicine, 1994 Oct.
author: Simopoulous, AP, Dr. PHD
Center for Genetics, Nutrition and Health, Washington DC.
conclusion of study: linoleic acid is positively related to insulin resistance,
linoleic acid is mainly associated with a western trans fatty acid diet.

2:) Title: Fatty acids, triglycerides and syndromes of insulin resistance
Prostalandins Leukot Essential Faty Acids, Oct. 1997
authors: Storlien LH, Kriketos AD, Calvert GD, Baur LA, Jenkins AB
Metabolic Research Centre and Department of Biomedical Science,
University of Wollongone, Australia email: I.storlien@uow.edu.au
conclusion of study: Linoleic acid inhigh amounts is known to inhibit edlta6 fatty acid desaturase enzynme and with competition between omega 6 and omega 3 fatty acids for the enzymes of desaturation and elongation, it does focus on high omega6/omega3 ratio and is a critical factor in both INSULIN RESISTANCE and atherosclerosis.

3:) Title:Dietary fat, genes and human health
Adv Exp Medical Biology 1997
authors: Jump DB, Clarke SD, Thelen A, Liimatta M, Ren B, Badin MV
Department of Physiology, Michigan Satte University, Eash Lansing, MI
conclusion of study: dietary fat, trans fatty acids directly have an effect on insulin resistance, especially long chain trans fatty acids.

4:) Title: Diet-induced insulin resistance precedes other aspects of the metabolic syndrome
Journal of Applied Physiology April 1998
authors: Barnard RJ, Roberts CK, Varon SM, Berger JJ
Department of Physiology Science, Univeristy of California, Los Angeles
conclusion of study: results demonstrate that insulin resistance and hyperinsulinemia occur before the other manifestations of the metabolic syndrome and that diet, not obesity is the underlying cause, early warning signs of hyperinsulienmia are high cholesterol, low HDL, high triglyerides, insulin stimulated glucose transport was significantly with a diet high in of trans fatty acids.

5:) Title: Skeletal muscle membrane lipid composition is related to adiposity and insulin action
Journal Clinical Investigation Biomedicine Dec. 96
authors: Pan DA, Lillioja S, Milner MR, Kriketos AD,
Bauer LA, Bogardus C, Storlien LH
Department of Endocrinology, Royal Prince Alfred Hospital, Syndey Australia
conclusion of study: results demonstrate that delta5 desaturase activity, ( polyunsaturated trans fatty acids) is independently related to both insulin resistance and obesity.

6:) Title: Current recommendations concerning rational use of fat.
Value of poluunsaturated fatty acids from the Omega 6 and Omega 3 groups
author: Okolska G, Ziemlanski S
Rocz Panstw Kalk Hig, Poland Medical University
conclusion of study: Long chain omega3 acids exert a beneficial effect on plasma lipid levels whereas trans fatty acids exert a negative influence, it is important in making the population aware of the importance of the introduction and modifications of the processed
food introduced by the food industry.

7:) Title: Mechanisms of fatty acid-induced inhibition of glucose intake
Journal of Clinical Investigation, June 1994
authors: Boden G, Chen A, Ruiz J, White JV, Rosseti L
Division of Endocrinology/Metabolism, Temple University School
of Medicine, Philadelphia, PA
conclusion of study: fatty acids caused a dose-dependent inhibition of insulin-stimulated glucose uptake(by decreasing glycogen synthesis and CHO oxidation) and that FFA and/or gylcerol increased insulin-suppressed hepatic glucose output and this caused insulin resistance at the peripheral and the hepatic levels.

8:) Title: Human adipose tissue in culture VS studies on the metabolic effects of insulin
Diabetologia Journal May 1976
authors: Smith U, Bostrom S, Johansson R, Nyberg G
conclusion of sudy: an acute antilipolytic effect of insulin could be demonstrated in the explants of tissues in short term incubations resulting from the input of hexokinase, glucose 6-phosphage dehygroenase (G6PDH), pyruvate kinase (PK) and lactate dehydrogenase (LDH) were increased in large fat cells, the stimulating effect of insulin of exerted on the membrane and the rate of glucose transport via fatty acids.

9:) Title: Skeletal muscle trigylceried levels are inversely related to insulin action
Diabetes 1997, June
authors: Pan DA, Lilloja S. Kriketos AD, Milner MR,
Baur LA, Bogardus C, Jenkins AB, Storlein LH
Department of Biomedical Science, University of Wollongong, NSW, Australia
conclusion of study: insulin sensitivity and effectiveness in strongly influenced by the local supplies of triglycerides as well as by remote depots of circulating lipids, high lipid oxidation and levels of triglycerides represented less glycogen synthesis and insulin action between mTG glucose, this may be central to the understanding of insulin resistance

10:) Title: The insulintropic potency of fatty acids if influenced profoundly
by their chain length and degree of saturation
Journal of Clinical Investigation, July 1997
authors: Stein DT, Stvenson BE, Chester MW, Basit M. DAniels MB, Turley SD, MaGarry JD
Department of Medicine, Center for Diabetes Research, Univeristy of Texas Southwestern Medical Center at Dallas Texas
conclusion of study: The lowering of elevated plasma FFA's caused a complete abation of subsequent glucose-stimulated insulin secretion, (GSIS). The effect of the NA was reversed when the fasting level of total FA was maintained by the coinfusion of soybean oil or lard, the more saturated animal fat proved to be far more potent in enhancing (GSIS), there was a broad difference on the type of essential fatty acids that make up the pool of fatty acids. Thus, for any given level of glucose, insulin secretion will be influenced greatly not only by the combined concentration of all unbound fatty acids, but also the makeup of the fatty acid pool.
11:) Title: Dietary lipids influence insulin action
American New York Academy of Science, June 1993
authors: Clandinin MT, Cheema S, Field CJ, Baracos VR
Nutrition and Metabolism Research Group, University of Edmonton Canada
conclusion of study: High levels of dietary omega3 fatty acids reduced PGE2 and PGF2 alpha synthesis in extensor digitorum longus and epitrochlearis muscles. Insulin increased glucose and amino acid transport, glucose transport ( effectiveness) by insulin was significantly greater after consumption of a high omega 3 essential fatty acids diet.

Media Links To Write
"Why are you not reporting this?"
Media Links

READ DL Dewey's
Previous Column
Hydrogenated Oils Are Silent Killers

HOME Previous Columns Email Contacts Advertising

©1997, 1998, 1999 Rocky Mountain Publicity
Updated October 7th, 1999
Email Contacts